Insulin resistance: Impact on therapeutic developments in diabetes
نویسندگان
چکیده
منابع مشابه
Developments in diabetes and insulin resistance.
This is the second in a series of articles on presentations at the American Diabetes Association Annual Meeting, San Diego, California, 10–14 June 2005. Alan Cherrington (Nashville, TN) gave the President’s Address at the American Diabetes Association (ADA) Annual Meeting, reviewing some of the progress, and lack thereof, occurring over the past 2 decades. In 1985, there were 6.4 million adults...
متن کاملOn diabetes: insulin resistance
Insulin is the most potent anabolic hormone known and is essential for appropriate tissue development, growth, and maintenance of whole-body glucose homeostasis. This hormone is secreted by the β cells of the pancreatic islets of Langerhans in response to increased circulating levels of glucose and amino acids after a meal. Insulin regulates glucose homeostasis at many sites, reducing hepatic g...
متن کاملOn diabetes: insulin resistance
The association of obesity with type 2 diabetes has been recognized for decades, and the major basis for this link is the ability of obesity to engender insulin resistance. Insulin resistance is a fundamental aspect of the etiology of type 2 diabetes and is also linked to a wide array of other pathophysiologic sequelae including hypertension, hyperlipidemia, atherosclerosis (i.e., the metabolic...
متن کاملOn diabetes: insulin resistance
The pathogenesis of type 2 diabetes is characterized by two major features: peripheral insulin resistance and impaired insulin secretion from pancreatic β cells (1, 2). The application of transgenic mouse technology to the study of diabetes has been extensively reviewed (3). Here, I review the application of a complementary approach, gene knockout technology, to the problem of understanding ins...
متن کاملOn diabetes: insulin resistance
In this paper I review the evidence that human sensitivity to insulin is influenced by heredity, in particular by one or more genes with relatively large effects. Even granting the existence of such genes, however, the best route toward identifying them — and the related genes that are presumed to affect an individual’s risk of obesity or type 2 diabetes — remains unclear. Thus, the phenotype o...
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ژورنال
عنوان ژورنال: Diabetes and Vascular Disease Research
سال: 2019
ISSN: 1479-1641,1752-8984
DOI: 10.1177/1479164119827570